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A型流感病毒毒力因子研究进展 被引量：5

Advances in Virulence Factors of Influenza virus
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摘要 A型流感病毒是致人和禽类感染、致病的重要病原体 ,病毒能否感染宿主和致病 ,其毒力是由多因子决定 ,并由基因组编码的 1 1种功能蛋白分工协作完成。流感病毒可通过表面抗原的变异逃避宿主保护性免疫 ;HA是毒力的主要决定因子 ,NA、PB2、NS1和新发现的 PB1 Influenza A virus is an important pathogen for human, and an enteric virus of many avian species. Virulence of influenza A virus is determined by multiple factors, and completed by the cooperation of the 11 coded functional protein. Antigenic variability of the 2 surface glycoproteins allows the virus to escape the host protective immunity. HA is the major virulence factor, whereas NA, PB2, NS1 and PB1-F1,the newly found protein, are involved in determination of virulence of influenza A virus.
作者 卢建红 邵卫星 龙进学 刘秀梵
机构地区 扬州大学农业部畜禽传染病学重点开放实验室
出处 《动物医学进展》 CSCD 2004年第4期63-66,共4页 Progress In Veterinary Medicine
基金 农业部农办牧项目资助 2 0 0 183
关键词 A型流感病毒 毒力因子 保护性免疫 血凝素 神经氨酸酶 内部基因产物 Influenza a virus virulence factor
分类号 S852.659.5 [农业科学—基础兽医学]
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参考文献23

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同被引文献68

  • 1张烨,温乐英,李梓,郭俊峰,王敏,郭元吉.2000～2002年我国流行的甲3(H3N2)亚型流感病毒抗原性及基因特性的研究[J].中华实验和临床病毒学杂志,2004,18(1):16-19. 被引量：21
  • 2钟文英,普雄明.热休克蛋白的分子生物学研究进展[J].医学综述,2005,11(2):148-150. 被引量：44
  • 3郭元吉,温乐英,张烨,王敏,郭俊峰,李梓,舒跃龙.猪在禽H9N2亚型流感病毒感染人中的作用[J].中华实验和临床病毒学杂志,2005,19(2):106-109. 被引量：5
  • 4Chen W, Calvo PA,Malide D,et al. A novel influenza A virus mitochondrial protein that induces cell death. Nat Med, 2001,7 (12): 1306-1312.
  • 5Henklein P, Bruns K, Nimtz M, et al. Influenza A virus protein PB1-F2:synthesis and characterization of the biologically active full length protein and related peptides. J Pept Sci, 2005, 11 ( 8 ) : 481-490.
  • 6Zell R, Krumbholz A, Eitner A, et al. Prevalence of PB1 -F2 of influenza A viruses. J Gen Virol,2007,88( Pt 2) :536-546.
  • 7Gibbs JS, Malide D, Hornung F, et al. The influenza A virus PB1 -F2 protein targets the inner mituchondrial membrane via a predicted basic amphipathic helix that disrupts mitochondrial function. J Virol, 2003,77 ( 13 ) :7214-7224.
  • 8Coleman JR. The PB1-F2 protein of influenza A virus: increasing pathogenicity by disrupting alveolar macrophages. Virol J, 2007, 4:9.
  • 9McAuley JL,Hornung F,Boyd KL,et al. Expression of the 1918 in- fluenza A virus PB1 -F2 enhances the pathogenesis of viral and sec- ondary bacterial pneumonia. Cell Host Microbe, 2007, 2 ( 4 ) :240-249. ~.
  • 10Li J, Qian X, Sha B. Heat shock protein 40:structural studies and their functional implications. Protein Pept Lett, 2009, 16 ( 6 ) : 606-612.

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动物医学进展
2004年 第4期

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