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甲氨蝶呤治疗类风湿关节炎作用机制的研究进展 被引量:7

Updates of mechanism study on methotrexate treating rheumatoid arthritis
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出处 《中国药物与临床》 CAS 2004年第7期497-499,共3页 Chinese Remedies & Clinics
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参考文献15

  • 1刘巧红,沈凌汛,滕云,王慧,陈燕,杨真荣.甲氨蝶呤对类风湿关节炎滑膜细胞增生及细胞周期的影响[J].中华风湿病学杂志,2004,8(4):223-226. 被引量:23
  • 2周惠琼,吴东海,马丽.短期小剂量甲氨蝶呤导致严重不良反应临床分析[J].中华风湿病学杂志,2002,6(2):135-138. 被引量:25
  • 3[3]Cutolo M, Sulli A, Pizzorni C, et al. Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis. Ann Rheum Dis,2001, 60(8): 729-735.
  • 4[4]Link AA, Kino T, Worth JA, et al. Ligand-activation of the adenosine A2α receptors inhibits IL-12 production by human monocytes. J Immunol, 2000, 164( 1 ): 436-442.
  • 5[5]Montesinos MC, Yap JS, Desai A. Reversal of the antiinflammatory effects of methotrexate by nonselective adenosine receptor antagonists theophylline and caffeine. Arthritis Rheum, 2000, 43(3): 656-663.
  • 6[6]Montesinos MC, Desai A, Delano D, et al. Adenosine A2α or A3receptors required for inhibition of inflammation by methotrexate and its analog MX-68. Arthritis Rheum, 2003, 48( 1 ): 240-247.
  • 7[7]Majumdar S, Aggarwal BB. Methotrexate suppresses NF-kappaB activation through inhibition of I kappa B alpha phosphorylation and degradation. J Immunol, 2001, 167 (5): 2911-2920.
  • 8[8]Cutolo M, Bisso A, Sulli A, et al. Antiprolfferative and anti-in-flammatory effects of methotrexate on cultured differentiating myeloid monocytic cells (THP-1) but not on synovial macrophages from rheumatoid arthritis patients. J Rheumatol, 2000, 27(11): 2552-2557.
  • 9[9]Genestier L, Paillot R, Foumel S, et al. Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells. J Clin Invest, 1998, 120(2): 322-328.
  • 10[10]de Lathouder S, Gerards AH, de Groot ER, et al. Mycophenolic acid and methotrexate inhibit lymphocyte cytokine production via different mechanisms. Eur Cytokine Netw, 2002, 13(3): 317-323.

二级参考文献18

  • 1蔡小燕,李翠贞.小剂量甲氨蝶呤引起急性骨髓抑制1例[J].广州医药,1995,26(3):62-62. 被引量:1
  • 2尹国华 张开明 邓联第.小剂量MTX治疗银屑病引起全血细胞减少致死1例[J].中国皮肤性病学杂志,1995,:162-162.
  • 3Fairbanks LD,Ckemann KR,Qiu Y,et al. Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes:a metabolic basis for efficacy in rheumatoid arthritis?Biochem J,1999,342:143-152.
  • 4Quemeneur L,Gerland LM,Flacher M,et al.Differential control of cell cycle,proliferation,and survival of primary T lymphocytes by purine and pyrimidine nucleotides. J Immunol,2003,170:4986-4995.
  • 5Sgambato A,Camerini A,Pani G,et al. Increased expression of cyclin E is associated with an increased resistance to doxorubicin in rat fibroblasts. Br J Cancer,2003,88:1956-1962.
  • 6Perlman H,Bradley K,Liu H,et al. IL-6 and matrix metalloproteinase-1 are regulated by the cyclin-dependent kinase inhibitor p21 in synovial fibroblasrs.J Immunol,2003,170:838-845.
  • 7Genestier L,Paillot R,Fournel S,et al. Immunosuppressive properties of methotrexate:apoptosis and clonal deletion of activated peripheral T cells.J Clin Invest, 1998,102:322-328.
  • 8黄晓舞 张信红.甲氨蝶呤治疗类风湿关节炎引起全血细胞减少并文献复习[J].药物与临床,1999,14:48-48.
  • 9Barrie M,Grace P,John DP.Neutropenia due to low-dose methotrexate therapy for psoriasis and rheumatoid arthritis may be fatal.Med J Aust,1991,155:480-484.
  • 10Debra M,Victoria P.Thrombocytopenia after a single test dose of methotrexate.J Am Acad Dermatol,1998,39:349-351.

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