摘要
目的研究马洛替酯治疗肝纤维化的组织学及超微结构改变。方法取雄性 Wistar 大鼠120只,随机分为3组,每组40只。模型组:CCl_4维0.25ml/100mg 皮下注射,每周三次;马洛替酯组:CCl_4油注射的同时予以马洛替酯50mg·kg^(-1)·d^(-1)灌胃,1次/日;对照组:橄榄油皮下注射。光镜及电镜下动态观察组织学改变,图象分析仪测量胶原面积。结果第四、六、八、十周,马洛替酯组肝纤维化分级、胶原面积低于模型组(P<0.05)。结论马洛替酯具有显著的抗肝纤维化作用。
To investigate the morphological change in rat liver after the treatment of malotilate.Methods 120 Wistar rats weighting about 250g were divided into 3 groups.Model group(n=40):The rats were injected with 40% CCL4 0.25ml/100g subcutaneously three times a week.Malotilate group(n=40):The rats were injected with 40% CCL4 0.25ml/100g subcutaneously three times a week.Malotilate equivalent to 50 mg·kg^(-1)·d^(-1) was given ig.Control group(n=40):the rats were injected with olive oil only.At 2,4,6,8,and 10 weeks,the animals were sacrificed.Mor- phological examined by Image Analyse system.Results Histological observation indicated that the grade of fibrosis and the area of collagen in malotilate group were less than those in model group after 2 weeks(P<0.05).Conclusion Malotilate can take fibrogenesis-inhibiting effect significantly.
出处
《现代消化及介入诊疗》
2000年第1期10-11,共2页
Modern Interventional Diagnosis and Treatment in Gastroenterology
基金
国家自然科学基金资助(基金号39870331)
