5-羟色胺基因多态性与抑郁症的相关性研究

Association study of serotonin transporter gene polymorphism and depression

目的 :探讨 5 羟色胺转运体 (5 HTT)基因启动子区多态性 (5 HTTLPR)与抑郁症的相关性及其对抗抑郁药疗效的影响。 方法 :运用聚合酶链反应技术 (PCR)检测 5 1例抑郁症患者 (患者组 )和 6 0名健康对照者 (对照组 ) 5 HTTLPR的分布频率 ;并予文拉法辛治疗 ,用汉密尔顿抑郁量表 (HAMD)观察疗效。 结果 :患者组 5 HTTLPR的短重复序列 /短重复序列 (short/short,S/S)基因型和短重复序列 (short,S)等位基因频率分别为 71%和 81% ,对照组为 4 5 %和 6 9%差异显著。治疗 4周后 ,长重复序列 /长重复序列 (long/long ,L/L)基因型患者的减分率显著高于其他两型。 结论 :5 HTTLPR的S/S基因型可能是抑郁症的易感基因之一 ,L/L基因型可能和更好的选择性 5 羟色胺受体阻滞剂类 (SSRIs)疗效有关。

Objective:To explore the association between depression and polymorphism of serotonin transporter (5-HTT) and its influence on the antidepressant response. Method:Using a polymerase chain reaction-based technique,polymorphism of 5-HTT-linked polymorphic region (5-HTTLPR) in serotonin transporter gene was determined in 51 patients with depression and 60 control subjects,the allelic and genotypic distributions in two groups were compared.Cases and controls were matched for ethnic and geographic origin.The patients were treated with venlafaxine and measured with Hamilton depression scale (HAMD). Results:The frequencies of 5-HTT short/short (S/S) genotype and allele S were significantly higher in depression patients than in controls(71% vs. 45%;81% vs.69%).The scores of long/long(L/L) genotype patients were significantly lower respectively than those of other genotypes. Conclusion:The findings support that the presence of 5-HTTLPR allele S may increase the risk for depression and that the L allele is associated with better SSRIs response.