2型糖尿病大鼠肾脏血管内皮生长因子的表达和黄芪的调节作用

Expression of Renal Vascular Endothelial Growth Factor in the Rat with Type Ⅱ Diabetes: the Regulatory Effect of Huangqi (Astragalus Root)

目的 观察黄芪对 2型糖尿病大鼠肾脏血管内皮生长因子 (VEGF)的影响。方法 将SD大鼠分为假手术组 (Sham组 )、糖尿病肾病组 (DN组 )、黄芪治疗组 (DNH组 )。DN组和DNH组制成糖尿病模型 ,DNH组予黄芪注射液 5mL kg灌胃。观察黄芪对糖尿病肾病大鼠肾组织VEGF、尿白蛋白的影响。结果 黄芪可明显降低糖尿病大鼠尿白蛋白及肾组织VEGF表达 (P <0 0 5 )。结论 2型糖尿病所致糖尿病肾病VEGF表达升高 ,黄芪可能通过抑制VEGF表达而减少糖尿病肾病损害。

Objective To observe the influence of huangqi (the dried root of Astragalus membranaceus or Astragalus membranaceus mongholicus) on renal vascular endothelial growth factor (VEGF) in the rat with type II diabetes. Method SD rats were divided into the sham-operation group,diabetic nephropathy group (DN group),and huangqi treating group (HTG). First,the rats in the latter two groups were induced to be with diabetic nephropathy,and then,the rats in the HTG group were intragastrically given Huangqi Injection at a dose of 5 mL/kg. The influence of huangqi on renal VEGF and on urinary albumin in the rat with diabetic nephropathy was observed. Results Huangqi could markedly decrease the level of urinary albumin and the expression of renal VEGF in the rat with diabetic nephropathy ( P <0.05). Conclusion The expression of renal VEGF increases in diabetic nephropathy due to type II diabetes,and huangqi can reduce the impairment by diabetic nephropathy through inhibiting the expression of renal VEGF.