温阳利水强心颗粒对大鼠胆固醇及血液流变性的影响

Effect of Qiang Xin Granules for Warming and Strengthening yang for Diuresis on the Cholesterol and Blood Rheology of Big Mice

目的:观察温阳利水强心颗粒穴WLQK雪对实验性大鼠高胆固醇血症的影响,对大鼠急性血瘀模型的影响。方法:采用高脂饲料喂养法喂养大鼠,使其形成高胆固醇血症模型,并同时通过灌胃给予受试药品,28d后取血测定血清胆固醇;给大鼠皮下注射大剂量肾上腺素加冷刺激形成血瘀模型,观察不同剂量WLQK的作用。结果:不同剂量WLQK均能使大鼠血清胆固醇降低,与模型组比较有显著性差异;对全血粘度有不同程度的改善作用,与模型组比较,差异显著穴P<0.0l或P<0.05雪。结论:WLQK可显著降低大鼠实验性高胆固醇血症的血清胆固醇,预防高脂血症;能有效调整、改善血液粘稠度。

Objective: To observe the effect of Qiang Xin Granules for warming and strengthening yang for diuresis (WLQK) on the high cholesterol and blood syndrome of tested mice and the acute blood stasis syndrome model of the mice. Method: Raised the mice with high fat forage and made them form a high cholesterol and blood syndrome model and at the same time infused them with the tested drug, and took the blood to measure serum and cholesterol in 28 days, then injected the mice with a large dosage of adrenaline and stimulated to form blood stasis syndrome model with cooling to observe the effects of the different dosage of WLQK. Result: The different dosage of WLOK can lower serum and cholesterol of the mice. It has an obvious difference comparing with the model group. It has a different effect on improving whole blood viscosity. The difference of the comparison with the model had a significance,P <0.01 or P <0.05. Conclusion: WLQK can remarkably lower the serum and cholesterol of the high cholesterol and blood syndrome of tested mice and prevent high fat syndrome, and has a good effect on the modulation and improvement of blood viscosity.