摘要
目的探讨人乳头瘤病毒(HPV)16型、18型与涎腺肿瘤病因学之间的关系。方法采用特异引物PCR法为44例涎腺肿瘤组织标本中31例HPVS阳性组织DNA进行分型检测。结果检出HPV16E7阳性率为13.60%,HPV18E7阳性率为47.72%,涎腺肿瘤组织中HPV18E7阳性率明显高于HPV16E7阳性率;恶性肿瘤组中HPV16E7和HPV18E7阳性率显著高于良性肿瘤组(P<0.05)。结论HPV18型感染与涎腺肿瘤的发生密切相关;HPV1618型E7基因在恶性肿瘤的发生中起重要作用。
Objective: To study the relationship between human papillomavirus (HPV) type 16, 18 infection and carcinogenesis of salivary gland tumor. Methods: A set of primers specific to HPV16E7 and HPV18E7, PCR method amplified the HPV16E7 and HPV18E7 gene in 31HPVs DNA positive cases of 44 salivary gland tumor tissues cases. Results: The positive rate of HPV16E7 gene was 13.6%, and HPV18E7 gene was 47.72% in salivary gland tumor. The positive rate of HPV18E7 in tumor was higher than that of HPV16E7. The positive rate of malignant tumor HPV16E7 and HPV18E7 was detected significantly higher than those of benign tumor (P <0.05). Conclusion: HPV type 18 infection is closely related to the pathogenesis of salivary gland tumor. The E7 gene of HPV16, HPV18 plays an important role in malignant transformation of cells.
出处
《中国现代医学杂志》
CAS
CSCD
2004年第16期61-63,共3页
China Journal of Modern Medicine
关键词
涎腺肿瘤
人乳头瘤病毒
聚合酶链反应
human papillomavirus
salivary gland tumors
polymerase chain reaction