脑梗死血清MMP-3的测定及临床意义

The Detection of Serum MMP-3 in Cerebral Infarction

目的 :观察脑梗死患者血清基质金属蛋白酶 3(MMP 3)的含量变化 ,探讨其在脑梗死发生发展过程中的作用和意义。方法 :用ELISA法检测 5 9例脑梗死患者发病 2 4h、5d、15d ,以及 32例健康体检者血清MMP 3的含量作对照。结果 :脑梗死发病 2 4h～ 5d的血清MMP 3水平显著高于对照组 (P <0 0 5 )。脑梗死组发病初期 (2 4h～ 5d)患者血清MMP 3水平明显增高 ,随脑梗死发病时间的延长 ,血清MMP 3水平逐渐降低 ,与对照组比较无显著差异(P >0 0 5 )。脑梗死发病 2 4h～ 5d的血清MMP 3水平与神经功能缺损程度评分 (脑卒中分值 )、空腹血糖、总胆固醇、三酰甘油均无明显相关性 (P >0 0 5 )。结论 :MMP 3在脑梗死发病早期过程中起着重要的作用 ,而且血清MMP 3水平的高低与临床病程有关。

Objective: To investigate the role and clinical significance of serum MMP-3 in cerebral infarction. Methods: Serum MMP-3 levels were measured in 59 cerebral infarction patients (during 24 h～15 days of the onset) and 32 healthy people by ELISA. Results: The level of MMP-3 during 24 h～5 days of the cerebral infarction is higher than those of control ( P < 0 05). No obvious relationship were observed between the levels of MMP-3 and the fast blood sugar (FBS),total serum cholesterol,and serum glycerol. Conclusion : MMP-3 may contribute the pathologic course in the early stage of cerebral infarction,and the level of MM P-3 is correlated with the clinical course of the disease.