纳洛酮对急性脑卒中意识障碍患者脑电信号的影响

Effects of naloxone on brain electrical signal in patients with disturbance of consciousness caused by stroke

目的:探讨盐酸纳洛酮治疗急性脑卒中致意识障碍的疗效及脑电信号的影响。方法:应用盐酸纳酮治疗急性脑卒中有意识障碍患者45例,与同期常规治疗该类患者45例进行比较。结果:治疗组疗效为94%(42/45),较对照组78%(35/45)好,治疗组转醒时间明显小于对照组。治疗组EEG明显改善,异常率低,为58%(26/45),与常规组78%(35/45)相比差异有显著性意义(χ2=21.159,P<0.01)。结论:盐酸纳洛酮治疗急性脑卒中致意识障碍,可明显缩短患者的转醒时间,显著提高疗效。

AIM:To explore the curative effect of naloxone in treating disturbance of consciousness caused by acute stroke and its influence on brain electrical signal. METHODS:Forty-five acute stroke patients with disturbance of consciousness were treated with naloxone(treatment group).Another 45 patients with the same symptom received routine treatment(control group).RESULTS:The curative effect in the treatment group(94%,42/45)was better than that in the control group(78%,35/45),and the time until the patients recovered from unconsciousness was shorter in the treatment group than the control group.The electroencephalogram(EEG)was improved obviously,and the abnormal rate was lowered(58%,26/45)in the treatment group,significantly different from those in the control group(χ2=21.159, P< 0.01). CONCLUSION:Naloxone may shorten the time until the patients recover from the unconsciousness and improve the curative effect for patients with disturbance of consciousness caused by acute stoke.