无症状脑梗死患者认知功能损害的P300特点

P300 characteristics of cognitive function damage in patients with asymptomatic cerebral infarct

目的:观察无症状脑梗死患者认知功能损害的P300特点为,探讨P300电位在评价其认知功能中的价值。方法:对新乡医学院第二附属医院符合1995年全国第四届脑血管病学术会议制定的诊断标准,排除既往有神经、精神病史及检查不合作的无症状脑梗死患者52例和50例健康成人分别进行了P300电位测定。结果:无症状脑梗死组P300电位成分中N2,P3波潜伏期和P3波幅分别为(255.0±22.6)ms,(357.6±25.9)ms,(3.8±1.8)μV,较对照组延长或降低,差异有显著性意义(t=2.25,2.53,2.60,P<0.05)。结论:无症状脑梗死患者存在认知功能障碍,P300电位可作为评价其认知功能的指标应用于临床。

AIM:To observe the P300 characteristics of cognitive dysfunction in patients with asymptomatic cerebral infarct(ACI),and to explore the value of P300 potentials in the evaluation of the cognition of ACI patients. METHODS:P300 potentials were tested in 52 ACI patients and 50 normal healthy controls.All the ACI patients were selected from the Second Affiliated Hospital of Xinxiang Medical College,who were in accordance with the diagnostic criteria raised by the Fourth National Academic Meeting about Cerebrovascular Disease in 1995,but those with the disease history of psychiatry or mental disease and incooperation in examination were excluded. RESULTS:The latencies of N2 and P3 and wave amplitude of P3 of P300 potentials in the ACI group were(255.0±22.6) ms,(357.6±25.9)ms and(3.8±1.8) μV,significantly prolonged or decreased as compared with those in the control group(t=2.25,2.53,2.60,P< 0.05). CONCLUSION:The patients with ACI have cognitive dysfunction,and P300 potentials can be used as an index in clinic for evaluating their cognitions.