代谢综合征患者胰岛素抵抗的影响因素

An Analysis of the Influential Factors of Insulin Resistance in Subjects with the Metabolic Syndrome

为探讨代谢综合征患者胰岛素抵抗的影响因素。对 12 6 1例年龄在 2 0～ 6 2岁机关职员的调查资料进行分析 ,代谢综合征诊断标准参考NCEP ATPⅢ标准 ,修改腹部肥胖的指标 (腰围男 >90cm ,女 >80cm) ,用稳态模式评估法的胰岛素抵抗指数 (HOMA IR)评价胰岛素抵抗。男女代谢综合征的患病率分别为 11.4 %和 10 .3% ,男女患病率之间差异无显著性意义 ;男女代谢综合征组的HOMA IR指数均高于非代谢综合征组 ;代谢综合征患者的逐步回归分析发现 ,空腹血糖、甘油三酯和腰围与HOMA IR呈独立相关。空腹血糖、甘油三酯和腰围是影响代谢综合征患者胰岛素抵抗程度的因素。

Aim To investigate the factors causing insulin resistance in subjects with the metabolic syndrome (MS). Methods 1261 administrative officers aged 20～62 years were studied for the MS using Adult Treatment Panel Ⅲ (ATP Ⅲ) criteria but with a modified waist circumference appropriate for Chinese (men>90 cm,women>80 cm). Insulin resistance was calculated using the Homeostasis Model Assessment (HOMA) equation. Results The prevalence of the MS was 11.4% and 10.3% in men and women,respectively. There was no significant difference in prevalence of the MS between men and women. HOMA-IR index of the MS group significantly higher than that of control in both sexes. Multiple stepwise regression suggested fasting plasma glucose level,triglyceride level,and waist circumference significantly associated with HOMA-IR among components of the MS. Conclusion The factors causing insulin resistance in subjects with the MS were fasting plasma glucose level,triglyceride level,and waist circumference.