摘要
目的研究石菖蒲对小鼠脑组织氨基酸类神经递质的影响,分析作用机制。方法石菖蒲不同部位提取物灌胃,用高效液相色谱法测定小鼠脑组织氨基酸类神经递质的含量。结果石菖蒲挥发油、水提液、去油水煎液可使大鼠谷氨酸(Glu)水平显著降低,挥发油、水提液使天门冬氨酸(Asp)含量降低,挥发油组的牛磺酸(Tau)含量也有较明显降低。结论石菖蒲可降低小鼠脑组织兴奋性氨基酸的含量,对脑细胞有保护作用。
Objective To study the effects of Rhizoma Acori Tatarinowii (RAT) on amino acids neurotransmitter in mice brain and to explore its mechanisms. Methods After treated by different parts of RAT,the cerebral contents of the amino acids neurotransmitter in rats were detected by high performance liquid chromatography (HPLC) Results Volatile oil, fluid extract and defatted decoction of RAT could significantly lower cerebral glutamic acid level. Volatile oil and fluid extract decreased the content of aspartic acid, and volatile oil could also reduce the taurine content in brain tissue. Conclusion RAT can lower the contents of excitatory amino acids(EAA ) and has protective effect on the brain.
出处
《中药新药与临床药理》
CAS
CSCD
2004年第5期310-311,共2页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
广东省中医药管理局资助项目(编号B01024)
广州中医药大学总体规划项目(编号C01010)
关键词
石菖蒲
氨基酸
神经递质
小鼠
Rhizoma Acori tatarinowii
Amino acid
Neurotransmitter
Mouse
