健脾补肾法治疗精神分裂症认知损害的临床观察

Clinical Observation of the Treatment of Cognitive Impairment in Schizophrenia by the TCM Therapy of Enforcing Spleen and Nourishing Kidney

目的 研究健脾补肾法治疗精神分裂症认知损害的疗效。方法 将 6 0例精神分裂症认知损害患者随机配对分为中药治疗组和安慰剂组 ,另选 30例正常人为正常对照组。中药治疗组患者服用氯丙嗪的同时服用健脾补肾方药 ,安慰剂组患者服用氯丙嗪的同时服用安慰剂。正常对照组不用任何治疗方法。中药治疗组被试和安慰剂组被试分别在入组前和研究结束时 ,正常对照组被试在入组时做划消测验法、《临床记忆量表》和威斯康星卡片分类测验 (WCST)测查。结果 治疗组注意、记忆和执行任务能力治疗前后比较 ,与安慰剂组比较有显著性差异 (P <0 0 5 )。

Objective To investigate the efficacy of the TCM therapy of enforcing spleen and nourishing kidney (TESNK) in the treatment of cognitive impairment in schizophrenia (CIS). Method 60 Cases of CIS were randomly divided into the TCM group and the placebo group. 30 Normal subjects were included in the normal control group. The TCM group was given chloropromazine plus TCM drugs for enforcing spleen and nourishing kidney, the placebo group was given chloropromazine plus placebo, and the normal control group was not given any treatment. Patients in both the TCM group and placebo group were examined by the Digit Canceling Task scale, clinical Memory scales, and Wisconsin Card Sorting Test before and after they were treated, and the subjects in the normal control group were examined by the same methods. Results It was found that there was significant difference between the criteria of attention, memory and task performance of the patients in the TCM group and those of the patients in the placebo group (P<0.05). Conclusion TESNK has an improving effect against cognitive impairment in schizophrenia.