拉莫三嗪在有效血药浓度时对脑电波的影响

The Influence of Lamotrigine on EEG at Therapeutic Serum Concentration

目的:研究拉莫三嗪在有效治疗血药浓度范围内,对癫痫发作间歇期痫样放电及α节律的影响。方法:92例病人分别在服拉莫三嗪前及服药后第3个月,第6个月检查脑电图,检测拉莫三嗪血药浓度。发作间期痫样放电定量采用Marciani定量标准,HPLC技术测定拉莫三嗪血药浓度,浓度对比采用自身对照t检验。结果:脑电图有痫样放电者66例,服药后3个月痫样放电减少者52例(77.79％),拉莫三嗪血药浓度(3.9±2.9)μg/mL,α节律差异无显著性。结论:拉莫三嗪在有效治疗血药浓度范围(1～8μg/mL)之内时,拉莫三嗪可使发作间期痫样放电减少,不影响脑电的背景活动。

Objective;To study the influence of lamotrigine with effective therapeutic serum concentration on interictal EEG. Method; EEG was examined before and at months 3 and 6 after lamotrigine was taken among 92 patients, and lamotrigine serum concentration tested after lamotrigine was taken for 3 and 6 months. The criteria of interictal epilepsy discharge quantity was recommended by Marciani, the concentration of lamotrigine was determined by HPLC, and statistics method was self-control paired-samples T test. Result; Improvement on EEG occurred in 52 of 66 patients with interictal epilepsy discharge after lamotrigine was taken for 3 months, the reduction percentage among patients with interictal epilepsy discharge was 77.79% when the concentration of lamotrigine was at 3. 9 ± 2. 9 μg /mL, there was no effect on arhythm. Conclusion; The numbers of interictal epilepsy discharge were decreased by lamotrigine and there was no effect on a rhythm when the concentration was at therapeutic levels (1 ~ 8 μg/mL).