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异丙酚作用机制研究概况 被引量：19

The Action Mechanism of Propofol
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摘要 随着神经生理学、分子生物学和PET(正电子发射断层扫描 )等新技术的应用 ,有关异丙酚作用机制的研究已有所进展。现就异丙酚脑摄取、异丙酚对脑血流和脑代谢的影响以及对γ 氨基丁酸受体复合体 (GABAreceptorcomplex)、N 甲基 D 天冬氨酸 (NMDA)受体的影响等方面 ,总结异丙酚全麻作用的可能机制。
作者 于冬男 林春水 古妙宁
机构地区 第一军医大学南方医院麻醉科
出处 《国外医学（麻醉学与复苏分册）》 2004年第4期237-239,共3页 Foreign Medical Sciences(Anesthesilolgy and Resuscitation)
关键词 异丙酚 作用机制 脑血流 脑代谢 γ-氨基丁酸受体复合体
分类号 R614 [医药卫生—麻醉学]
  • 相关文献

参考文献20

  • 1盖成林,古妙宁,林春水,欧阳铭文,周俊岭.异丙酚麻醉诱导期间动脉和颈内静脉球部血药浓度的变化[J].中华麻醉学杂志,2002,22(4):197-199. 被引量：8
  • 2古妙宁,盖成林,林春水,欧阳铭文,徐建设,周俊岭.恒速静脉输注异丙酚时脑摄取的研究[J].中华麻醉学杂志,2001,21(3):133-135. 被引量：16
  • 3Liachenko S, Tang P, Somogyi GT,et al. Comparison of anaesthetic and non-anaesthetic effects on depolarization-evoked glutamate and GABA release from mouse cerebrocortical slices. Br J Pharmacol, 1998, 123:1274-1280.
  • 4KrasowskiMD, Koltchine VV, Rick CE, et al. Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane. Mol Pharmacol, 1998,53: 530-538.
  • 5Enlund M, Andersson J, Hartvig P, et al. Cerebral normoxia in the rhesus monkey during isoflurane- or propofol-induced hypotension and hypocapnia,despite disparate blood-flow patterns: a positron emission tomography study. Acta Anaesthesiol Scand, 1997, 4
  • 6Matthew DK, Andrew J, Pamela F, et al. General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of γ-aminobutyric acid (GABA) current at the GABAA receptor but not with lipid solubility. J Pharmacol exp ther, 2
  • 7Ludbrook GL, Upton RN, Martinez GA. Prolonged dysequilibrium between blood and brain concentrations of propofol during infusions in sheep. Acta Anaesthesiol Scand, 1999, 43:206-211.
  • 8Alkire MT, Haier RJ. Correlating in vivo anaesthetic effects with ex vivo receptor density data supports a GABAergic mechanism of action for propofol, but not for isoflurane. Br J Anaesthesia, 2001,86(5):618-626.
  • 9McKeman RM, Whiting PJ. Which GABAA-receptor subtypes really occur in the brain? Trends Neurosci, 1996, 19:139-143.
  • 10Schofield PR, Darlison MG, Fujita N, et al. Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family. Nature, 1987, 328:221-227.

二级参考文献8

  • 1Richard N. Upton,Laurence E. Mather,William B. Runciman,Craig Nancarrow,Ronda J. Carapetis. The use of mass balance principles to describe regional drug distribution and elimination[J] 1988,Journal of Pharmacokinetics and Biopharmaceutics(1):13～29
  • 2Peacock JE,Blackburn A,Sherry KM,et al.Arterial and jugular venous bulb blood propofol concentrations during induction of anesthesia[].Anesthesia and Analgesia.1995
  • 3Berthoud MC,McLauch GA,Broome H,et al.Comparison of infusion rates of three iv anaesthetic agents for induction in elderly patients[].British Journal of Anaesthesia.1993
  • 4Goodman NW,Black AMS.Rate of injection of propofol for induction of anesthesia[].Anesthesia and Analgesia.1992
  • 5Dundee JW,Hassard TH,McGowan WAW,et al.The induction dose of thiopentone[].Anaesthesia.1982
  • 6Pavan I,Buglione E,Massiccio M,et al.Monitoring propofol serum levels by rapid and sensitive reversed-phase high-performance liquid chromatography during prolonged sedation in ICU patients[].Journal of Chromatographic Science.1992
  • 7王若松,张兴安,陈宇柯,吴群林,魏涧崎,王卫权.靶控输注异丙酚和芬太尼全静脉麻醉[J].中华麻醉学杂志,1998,18(11):645-648. 被引量：7
  • 8刘荣,招伟贤,肖广钧,蔡颖谦.异丙酚目标控制输注系统性能的临床研究[J].中华麻醉学杂志,1999,19(1):33-35. 被引量：20

共引文献26

同被引文献121

引证文献19

二级引证文献130

国外医学（麻醉学与复苏分册）
2004年 第4期

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