摘要
目的 探讨姜黄素对糖尿病大鼠肾脏病变的作用及对肾脏Smad7蛋白表达的影响。方法 诱导大鼠糖尿病后 ,随机分为对照组及治疗组 ,比较各组的血生化、尿微量白蛋白排泄量、肾脏病理改变及Smad7的免疫组化。结果 糖尿病大鼠内生肌酐清除率 (Ccr)、尿微量白蛋白 (mAlb)排泄量较正常鼠增多 ,系膜基质增生 ,Smad7表达明显下降 ;姜黄素治疗能明显降低Ccr (P <0 0 5 ) ,减少Alb排泄量 (P <0 0 5 ) ,抑制系膜基质增生 ,上调Smad7的表达 (P <0 0 5 )。结论 姜黄素对糖尿病肾病具有明显疗效 ,其机制至少部分是通过上调Smad7的表达 ,拮抗转化生长因子 β的作用 ,从而抑制肾脏纤维化。
Objective To explore the therapeutic effects of Curcumin on renal lesions and its influence on the expression of Smad7 in diabetic rats. Methods Diabetic rats were randomly divided into control group and experimental group treated with Curcumin. Blood biochemical parameters, 24-h urinary albumin excretion, renal pathology and the expression of Smad7 (immunohistochemistry) were compared among the groups.Results Compared with normal rats, Ccr and urinary albumin excretion were increased markedly in diabetic rats, while mesangial expansion and the expression of Smad7 were decreased. Treatment with Curcumin could markedly decrease Ccr and urinary albumin excretion, inhibit mesangial expansion and up-regulate the expression of Smad7. Conclusion Curcumin has therapeutic effects on diabetic nephropathy. The mechanism is, at least in part, through up-regulation of Smad7. Smad7 inhibits the effect of TGF-beta and then, inhibits renal fibrosis.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
2004年第4期438-440,444,共4页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
