摘要
D-(-)-α-苯甘氨酸是合成氨苄青霉素的原料,采用腈化物路线合成其的独到之处是在用L-(+)-酒石酸拆分DL-α-氨基-α-苯乙腈时,往其中加少量催化剂(酮类),可使D-型左旋体的收率提高到80％以上。
D-(—)-α-Phenylglycine is an intermedium in synthesis of ampicillin. A new synthetic route using nitrile was given. Its character is that DL-α-amino-α-phenylacetonitrile was treated with L-(+)-tartaric acid and a small amount of catalyst (ketone), and the yield of the D-laevoisomer could be increased to above 80％.
出处
《河北化工》
1993年第1期12-14,共3页
Hebei Chemical Industry
关键词
苯甘氨酸
氨苄青霉素
腈化物
D-(-)-α-phenylglycine, ampicillin, L-(+)-tartaric acid, DL-α-amino-α-phenylacetonitrile, nitrile, benzaldehyde
