摘要
目的 探讨联合检测尿五种蛋白对早期诊断糖尿病肾病的临床价值。方法 测定 10 4例 2型糖尿病患者 2 4h白蛋白 (Alb)、转铁蛋白 (TRF)、N 乙酰 β D氨基葡萄糖苷酶 (NAG)、免疫球蛋白 (IgG)、视黄醇结合蛋白 (RBP)以及空腹血糖、血尿素氮等指标。根据 2 4h尿白蛋白排泄率 (UAER)分为三组 ,第 1组 :正常白蛋白尿组 (UAER≤ 2 0 μg/min) ,6 1例 ;第 2组 :微量白蛋白尿组 (UAER 2 0~ 2 0 0 μg/min) ,2 5例 ;第 3组 :大量白蛋白尿组 (UAER≥ 2 0 0 μg/min) ,18例。三组之间进行统计学分析。 结果 ①三组间年龄、收缩压(SBP)、舒张压 (DBP)差异有显著意义 (P <0 0 5 )。②尿TRF、NAG、IgG和RBP在第 1组增高的频率为9 84 %、4 92 %、4 92 %、8 19% ;在第 2组增高的频率为 96 %、84 %、88%、5 2 % ;在第 3组增高的频率为10 0 %、88 89%、10 0 %、77 78%。③偏相关分析显示 :UAER与尿TRF、NAG、IgG和RBP排泄相关性明显 (r分别为 0 5 6 6 3、0 36 6 8、0 5 4 92和 0 10 77,前三项P均 <0 0 5 ,后者P =0 2 84 )。结论 尿五种蛋白联合检测对糖尿病肾病的早期诊断具有较大的临床价值。
Objective To explore the value of combined measurement of urinary five proteins in diagnosing diabetic nephropathy early.Methods 24 hour urinary ablumin(Alb),transferrin(TRF),IgG,retinal-bingding protein(RBP),N-acetyl-glucosaminidase(NAG),fasting blood glucose,blood creatinine(Scr) and so on were measured.104 patients were divided into three groups according to their 24h urinary albumin excretion rate(UAER),group 1(normal albuminuria),group 2(microalbuminuria) and group 3(macroalbuminuria),ststistics were done among three groups.Results (1)Age,sex,systolic blood pressure and diastolic blood pressure were of signicant defferent among three groups.(2)The raised prevalence rate of urinary TRF,NAG,IgG and RBP in group 1 were 9.84%,4.92%,4.92%,8.19%,respectively;The raised prevalence rate of urinary TRF,NAG,IgG and RBP in group 2 were 96%,84%,88%,52%,respectively;The raised prevalence rate of urinary TRF,NAG,IgG and RBP in group 3 were 100%,88.89%,100%,77.78%,respectively.(3)Urinary TRF,NAG and IgG had significant postive relationship with UAER(r 1=0.5663,r 2=0.3668,r 3=0.5492,P<0.05).Conclusion Urinary five proteins combination measurement have clinical value for the diagnosis of diabetic nephropathy early.
出处
《中国临床保健杂志》
CAS
2004年第6期415-417,共3页
Chinese Journal of Clinical Healthcare
关键词
糖尿病肾病
尿蛋白
诊断
Diabetic nephropathy
Urinary protein
Diagnosis