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胃癌幽门螺杆菌感染与P16、CD44V6的表达及意义 被引量：6

Expression and relationship among CD44V6 with P16 in gastric cancer with Helicobacter pylori infection.
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摘要 目的　研究幽门螺杆菌 (Helicobacterpylori,HP)感染胃癌中CD4 4V6与P16表达及相互关系。方法　 96例经胃镜及病理证实的胃癌标本 ,应用免疫组化染色法检测CD4 4V6与P16表达。HP感染由快速脲酶试验结合Warthin -Starry银染色确定。结果　胃癌中HP阳性的病人与HP阴性的病人相比较 ,HP阳性的病人P16表达显著低于HP阴性的病人 (P <0 0 1) ;CD4 4V6表达HP阳性的病人显著高于阴性的病人 (P <0 0 1) ;HP感染的胃癌中P16表达与CD4 4V6表达呈负相关 (rs =0 75 2 1,P <0 0 1)结论　CD4 4V6与P16基因在胃癌中起了非常重要作用。HP感染直接或间接的促进了CD4 4V6的表达 ,并抑制了P16的表达。 Objective To determine the expression and relationship between CD44V6 and P16 in gastric cancer with HP infection. Methods Expression of CD44V6, and P16 were investigated in 96 gastric cancer by using immunohistochemistry. HP was examined by both of Warthin -Starry method and RUT. Results HP positive group compare with HP negative group in gastric mucosal lesions, Expression of P16 in HP positive group was lower than that in HP negative(P<0.01);Expression of CD44V6 in HP positive group were higher than that in HP negative group(P<0.01).Expression of P16 was significantly correlated with expression of CD44V6 in gastric cancer with HP infection(rs=-07431,P<0.01).Conclusion Expression of P16,and CD44V6 play an important role in gastric cancer.[
作者 张素青 刘继斌 施民新 邵世和
机构地区 南通市肿瘤医院 江苏大学
出处 《现代肿瘤医学》 CAS 2004年第5期408-410,共3页 Journal of Modern Oncology
关键词 幽门螺杆菌 CD44V6 P16 HP P16 CD44V6 gastric conicer
分类号 R735.2 [医药卫生—肿瘤]
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共引文献936

同被引文献46

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现代肿瘤医学
2004年 第5期

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