无锡地区散居儿童粪便幽门螺杆菌抗原的流行病学研究

Epidemiological research of the antigen of Helicobacter pylori in stool of scattered inhabiting children in Wuxi area

目的 了解无锡地区儿童人群中幽门螺杆菌 (Hp)感染情况 ,探讨影响Hp感染的因素。 方法 采用酶联免疫方法检测 112 6例 0～ 12岁儿童粪便中的幽门螺杆菌抗原 (HpSA)。结果 该地区儿童HpSA平均阳性率为 19.0 9% ,且有随年龄增长而递增趋势。其中男性为 19.6 2 % ,女性为 18.5 2 % ,二者差异无显著性 (P >0 .0 5 )。有症状组HpSA阳性率为 2 6 .94 % ,高于无症状组 10 .6 0 % (P <0 .0 1)。城区儿童HpSA阳性率为 12 .4 7% ,城郊结合部儿童为 19.30 % ,郊区、农村儿童为 2 4 .94 %。十二指肠球部溃疡小儿的HpSA阳性率为90 .77%。结论 该地区儿童人群中Hp感染率较高 ,是引起儿童胃十二指肠疾病的主要原因。

Objective To investigate Helicobacter pylori (Hp) infection in children population of Wuxi area and explore the influential factors of Hp infection. Methods Hp antigen in the stool specimens of 1 126 children aged between 0 and 12 years old were detected with ELISA method. Results Average Hp positive rate of the population was 19.09% . There was an increased tendency with growing age, the male was 19.62% and the female 18.52% , there was no significant difference between them. Hp positive rate was 26.94% in symptomatic group and 10.60% in asymptomatic group (P< 0.01 ). Hp positive rate in city, the city-rural conjunct area and rural area was 12.47% , 19.30% and 24.94% respectively. The Hp positive rate in children with gastroduodenal ulcer was 90.77% . Conclusion Hp infection rate is higher in children population of Wuxi area, which is the main cause of children's gastroduodenal diseases.