摘要
目的 :观察冬虫夏草提取物 (CSE)对实验性衰老小鼠的抗衰老作用及机制。方法 :以D 半乳糖致亚急性衰老小鼠为模型 ,同时给予CSE 1,2 ,4g·kg-1治疗 ,6周后 ,以学习记忆成绩、超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GSH Px)、过氧化氢酶 (CAT)、脑中单胺氧化酶 (MAO)、Na+ K+ ATP酶、过氧化脂质为指标 ,观察CSE延缓衰老作用。结果 :表明CSE能有效提高衰老小鼠的学习记忆成绩 ,不同程度提高衰老小鼠肝、脑、红细胞SOD及全血GSH Px ,CAT活性 ,提高脑中Na+ K+ ATP酶活性 ,降低脑中MAO活性 ,降低肝、脑MDA含量。结论 :CSE能有效防止D 半乳糖致衰老小鼠的多项衰老体征的出现 ,具有明显的延缓衰老作用 ,其作用机理可能与其提高抗氧化酶活性、清除自由基。
Objective: To investigate anti-aging effect and mechanism of Cordyceps extract(CSE) on aged mice induced by D-galactose. Method: The aged mice were induced by D-galactose. Meanwhile, they were treated with three doses of CSE. Then the ability of learning and memory, the activity of antioxidase in the different tissue, the contents of MDA of brain and liver were measured after 6 weeks. Result: CSE could significantly increase the ability of learning and memory, improve the activity of SOD of red blood cells, brain and liver, the activity of Na^+-K^+-ATPE of brain, the activity of CAT and GSH-Px of blood, and remarkably decrease the activity of MAO of brain and the contents of MDA of brain and liver. Conclusion:CSE has good anti-aging effects on the aged mice, which is probably due to effects of improving antioxidation and removing free radicals.[
出处
《中国中药杂志》
CAS
CSCD
北大核心
2004年第8期773-776,共4页
China Journal of Chinese Materia Medica
基金
国家自然科学基金资助项目 ( 3 93 0 0 0 173
3 9470 0 5 8)
