儿童幽门螺杆菌感染与厌食及发锌含量的关系

The relationship between helicobacter pylori infection and hair concentration of trace element znic and anorexia in children

①目的 探讨儿童幽门螺杆菌 (Hp)感染与厌食及发锌含量的关系。②方法 将 2 74例儿童分为厌食组 1 50例及正常组(对照组 ) 1 2 4例 ,用酶联免疫吸附法检测血清Hp抗体及粪便Hp抗原 ,两者均阳性诊断为Hp感染。血清抗体阴性为非Hp感染。同时采集发样 ,进行发锌含量的测定。对诊断为Hp阳性的儿童进行三联疗法的根除治疗 ,治疗后再测发锌含量。③结果 厌食儿童Hp感染率 (47.33 % )明显高于正常对照组 (31 .45 % ) (χ2 =7.1 3 ,P <0 .0 1 ) ;Hp阳性的儿童发锌含量 (1 0 2 .67± 9.63) μg/ g ,明显低于Hp非感染组 (1 1 9.0 7± 1 0 .87) μg/ g(t=- 1 2 .81 ,P <0 .0 0 1 ) ;Hp阳性的儿童治疗后发锌含量 (1 1 7.43± 1 0 .0 8) μg/ g ,明显高于治疗前 (t=1 1 .72 ,P <0 .0 0 1 ) ,且与Hp阴性儿童比较无显著性差异 (t=1 .2 6 ,P =0 .2 0 74)。④结论 儿童厌食与Hp感染有关 ,Hp感染能导致发锌含量的降低。

Objective To explore the relationship between HP infection and hair concentration of trace element znic and anorexia in children.Methods 274 children,divided into two groups by having anorectic symptoms or not. Stool Hp antigen was measured with Enzyme-linked immunosorbent assay(ELISA)among individuals who were anti-HpU-IgG seropositive.Hp status was defined as positive when both serum and stool antigen tests were positive,Hp status was defined as negative when serum antibody test was negative.Triple therapeutic scheme was adopted to treat Hp infection.Results Positive rates of Hp were 47.33% and 31.45% in asymptomatic children and in children with anorectic symptoms.The latter was significantly higher than the former.The hair concentration of znic in children with Hp infection was significantly lower than that without Hp infection. The hair concentration of znic was increased significantly after therapy.Conclusion Hp infection may bring on deficiency of znic and anorexia in children.