摘要
报告黄芩甙对细胞免疫功能的影响。结果表明,低剂量黄芩甙可明显促进ConA诱导的小鼠脾淋巴细胞增殖反应,高剂量则显著抑制。低剂量黄芩甙对LPS诱导淋巴细胞增殖反应有促进作用,但无统计学意义,高剂量可显著抑制淋巴细胞增殖。黄芩甙可明显提高小鼠脾脏单个核细胞中cAMP含量,对cGMP无影响。体内用药对巨噬细胞吞噬中性红的作用,低剂量显著升高,高剂量明显抑制。但体外用药均明显抑制巨噬细胞吞噬中性红的作用。
e investigaed the cellular immunological effects of
baicalin in mice. The results are as fol-lows,Low doses of baicalin markedly increased Con
A-induced lymphocyte proliferation of mousespleen cell in vitro, but high doses of baicalin
inhibited it significantly. Baicalin of low doses en-hanced LPS-induced lymphocyte
proliferation(with no statistical significance),but high dosesshowed significaiit inhibition.
Baicalin markedly increases cAMP Ievel of mouse spleen moiionu-clear cells in vivo,but had no
effect on cGMP. Baicalin at low doses markedly enhanced the func-tion of ingestion of mouse
peritoneal macrophages in vivo, but high doses showed significant inhi-bition. It markedly
inhibited the function of mouse macrophages in vitro.
出处
《南京铁道医学院学报》
1994年第2期65-68,共4页
Journal of Nanjing Railway Medical College
基金
江苏省应用基础研究