自拟补肾健脾通络汤对骨质疏松症患者疼痛及骨密度的影响

Effect of the self-made bushen jianpi tongluo decoction on pain and bone mineral density of patients with osteoporosis

目的:观察自拟补肾健脾通络汤对骨质疏松症患者疼痛的改善作用,评价其对骨质疏松患者骨密度的影响,分析其治疗机制。方法:深圳市中医院共收治125例原发性骨质疏松症患者,其中采用自拟补肾健脾通络汤治疗骨质疏松患者64例(治疗组),并与中成药治疗骨质疏松患者61例(对照组)进行对比观察。结果:对骨质疏松患者疼痛的改善作用两组间有效率(分别为84%和67%)差别有显著性意义(χ2=301.5,P<0.01),两组间骨密度的改善情况有显著差别,治疗组治疗后腰椎、股骨颈、股骨三角区的骨密度为(0.965±0.088),(0.702±0.048),(0.706±0.033)g/cm2,对照组的值为(0.933±0.036),(0.685±0.035),(0.671±0.036)g/cm2(t=2.314～5.6,P<0.05),两组患者治疗前后血生化指标对比有显著差别,治疗组治疗后S-Ca为(2.342±0.113)mmol/L,Ca2+为(2.02±0.14)mmol/L,ALP为(64.3±12.1)nkat/L,对照组的值为(2.309±0.145),(2.34±0.28)mmol/L,(70.3±12.7)nkat/L(t=2.04～5.47,P<0.05)。结论:自拟补肾健脾通络汤对骨质疏松患者的疼痛及骨密度的改善作用明显,疗效稳定,无副作用。

AIM:To observes the effect of self made bushen jianpi tongluo decoction in ameliorating pain of patients with osteoporosis, and to evaluate its effect on their bone mineral density(BMD),and analyze the treating mechanism. METHODS:A total of 125 patients with essential osteoporosis,who were treated in the Shenzhen Hospital of Traditional Chinese Medicine,were randomly divided into treated group(n=64,receiving treatment of bushen jianpi tongluo decoction) and control group(n=61,receiving treatment of Caltrate and yishen jiangu tablet),and then the results were compared. RESULTS:The effective rate of ameliorating pain in the treatment group (84%) was significantly different from that in the control group(67%) (χ2=301.5,P< 0.01).There were significant differences in the improvement of BMD between the two groups,the BMD in lumbar spine, neck of femur and femoral triangle in the treatment group were(0.965±0.088), (0.702±0.048)and (0.706±0.033) g/cm2,in the control group were(0.933±0.036),(0.680±0.035)and (0.671±0.036) g/cm(t =2.314 to 5.6,P< 0.05).There were significant differences in the blood biochemical indexes before and after treatment in both groups, After treatment, the S Ca,Ca2+and ALP in the treatment group were(2.342 ±0.113) mmol/L (2.02±0.14) mmol/L and(64.3±12.1)nkat/L,in the control group were(2.309±0.145) mmol/L,(2.34±0.28) mmol/L and (70.3±12.7) nkat/L(t=2.04 to 5.47,P< 0.05). CONCLUSION:The self made bushen jianpi tongluo decoction had obvious effects in improving pain and BMD of patients with osteoporosis,the curative effect is steady and side effect is not found.