摘要
目的:探讨鼻咽癌组织中MMP-9、CD44v6蛋白表达与鼻咽癌侵袭转移和患者预后的关系。方法:采用免疫组化LSAB法检测100例存档、石蜡包埋鼻咽癌组织中MMP-9、CD44v6蛋白表达,并分析其与各临床指标和患者总生存率之间的关系。结果:鼻咽癌组织中MMP-9蛋白表达阳性率为85.0%(85/100),其中(+)23.0%,(++)53.0%,(+++)9.0%。CD44v6蛋白表达阳性率63.5%(60/96),其中(+)37.5%,(++)8.3%,(+++)16.7%。MMP-9表达(+++)的鼻咽癌患者总生存率显著低于MMP-9表达(-)、(+)、(++)的患者。CD44v6表达为(-)、(+)、(++)、(+++)的各组鼻咽癌患者之间的总生存率无差异。鼻咽癌组织中MMP-9和CD44v6表达与患者年龄、性别、T分期、N分期及92’分期无关。结论:鼻咽癌组织中MMP-9、CD44v6蛋白表达与患者年龄、性别、颈淋巴结转移无关。MMP-9蛋白表达强阳性提示患者预后差。
Objective: To investigate the correlation of MMP-9 and CD44v6 protein expression with tumor invasiveness, metastasis and prognosis of nasopharyngeal carcinoma (NPC) patients. Methods: 100 primary NPC were examined for MMP-9 and CD44v6 protein expression by immunohistochemistry LSAB method. Results: MMP-9 staining was positive in 85of 100 (85%) NPC, including 23 of '+', 53 of '++', 9 of '+++'. CD44v6 staining was positive in 60 of 96 (63.5%) NPC, including 60 of '+', 8 of '++', 16 of '+++'. There was no significant correlation of MMP-9 and CD44v6 expression with age, gender, and TNM stage of NPC patients. The patients with MMP-9 '+++' expression in NPC revealed poorer overall survival compared with those with MMP-9 '++' or '+' expression or negative patients. CD44v6 expression in NPC did not correlated with overall survival in NPC patients. Conclusion: No significant correlation of CD44v6 and MMP-9 expression with age, gender, and TNM stage of NPC patients was observed. Those NPC patients with MMP-9 protein strong positive expression indicated poor prognosis.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2004年第20期1153-1156,共4页
Chinese Journal of Clinical Oncology
基金
国家重大基础研究规划"973"计划基金资助(编号:G1998051201)
关键词
鼻咽肿瘤
MMP-9
CD44V6
预后
Nasopharyngeal carcinoma Matrix Metalloproteinases-9
CD44-Variants 6 Prognosis