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超分割放疗联合化疗Ⅲ期和Ⅳ期鼻咽癌前瞻性研究 被引量:1

Combined hyperfractionated radiotherapy and concurrent chemotherapy for stage Ⅲ-Ⅳ nasopharyngel carinoma
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摘要 目的 :比较超分割加同期化疗与单纯超分割放射治疗Ⅲ~Ⅳ期鼻咽癌的生存率和局部控制率。方法 :12 6例鼻咽癌患者 ,随机分入超分割加同期化疗组 (研究组 )和单纯超分割放射治疗组 (对照组 )。放射治疗方式 2个组相同 ,1 2Gy/次 ,2次 /天。研究组在放射治疗前、中加用化疗 ,放疗、化疗同期进行。结果 :研究组和对照组 5年生存率分别为 6 6 7%和5 0 8% (P <0 0 5 ) ,局部控制率分别为 96 8%和 92 1% (P >0 0 5 )。研究组的急性粘膜反应高于对照组 ,但能耐受 ,无严重并发症发生。结论 :超分割放射同期化疗Ⅲ~Ⅳ期鼻咽癌生存率和控制率有所提高 ,且能耐受。 Objective:To compare the local control and survival rates of hyperfractionated radiotherapy plus concurrent chemotherapy with hyperfractionated radiotherapy alone in the treatment of stage Ⅲ-Ⅳnasopharyngel carcinoma (NPC).Methods:126 NPC patients were randomized into hyperfractionated radiotherapy plus concurrent chemotherapy (R+C) and hyperfractionated radiotherapy alone (R alone) groups. Radiotherapy were similar in the two groups: 1.2/Gy/f, twice a day. Chemotherapy was given to R+C patients before and during the course of radiotherapy. Results:The 5-year survival rates of the R+C and R alone groups were 66.7% and 50.8%, with the difference statistically significant (P<0.05). The 5-year local control rates were 96.8% and 92.1% (P>05). The acute mucosal reaction in the R+C patients was severer than that of the R alone, but well tolerated and did not develop any severe complications. Conclusion:Hyperfractionated radiotherapy plus concurrent chemotherapy can improve the local control and survival in patients with stage Ⅲ-Ⅳnasopharyngel carcinoma with well tolerated mucosal reaction.
出处 《临床肿瘤学杂志》 CAS 2004年第5期471-472,478,共3页 Chinese Clinical Oncology
关键词 鼻咽癌 化疗 对照组 生存率 超分割放疗 同期 超分割放射治疗 局部控制率 前瞻性研究 耐受 Nasopharyngel neoplasms/radiotherapy Nasopharyngel neoplasms/chemotherapy Prognosis
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