摘要
目的 研究二巯丙磺钠 (Na DMPS)对动物体内毒鼠强排泄的影响。方法 应用气相色谱 -氮磷检测器法测定染毒家兔的毒鼠强血浆浓度和尿液含量 ,并进行代谢动力学分析。结果 Na DMPS没有降低中毒动物血液中毒鼠强浓度 ,对各代谢动力学参数没有明显影响 ,亦未增加中毒动物 2 4h尿中毒鼠强含量。结论 Na DMPS不能加快毒鼠强从动物体内的排泄。
Objective To study the effect of sodium dimercaptopropane sulfonate(Na-DMPS) on excretion of tetramine(tetramethylenedisulphotetramine) in animals.Method The plasma and urine levels of tetramine in exposed rabbits were determined by gas chromatogram-nitrogen phosphorus detector (GC-NPD),the toxicokinetics of tetramine was also carried out.Result After administrated Na-DMPS,the plasma concentrations of tetramine were not decreased,all parameters of toxicokinetics were not changed obviously,and 24 hours urine contents of tetramine were also not increased remarkably.Conclusion Na-DMPS could not enhance the urinary excretion of tetramine from poisoned animals.
出处
《中国工业医学杂志》
CAS
北大核心
2004年第5期277-279,共3页
Chinese Journal of Industrial Medicine
基金
国家科学技术委员会国家重点科技项目 (编号为 96 92 0 37 1 9)