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新型抗抑郁药的代谢与细胞色素P450介导的药物相互作用 被引量:4

Metabolism of antidepressants and cytochrome P450 mediated drug-drug interactions
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摘要 新型抗抑郁药(选择性5-羟色胺再摄取抑制剂,SSRI)疗效肯定,耐受性好,已得到广泛应用。SSRI剂既是P 450酶的底物又是P 450酶的抑制剂,其重要特征是对P 450酶的抑制。当SSRI剂与P 450酶的其他底物合用时,可能发生明显的具有临床意义的药物相互作用。 Selective serotonin reuptake inhibitors(SSRIs) are new antidepressantswhich can inhibit serotonin reuptake selectively.They are extensively used in manycountries.SSRIs are substrates and inhibitors of CYP450 enzymes.When SSRIs areused concurrently with substrates of CYP450 isoenzymes, there is likelihood ofclinically important pharmacokinetic drug-drug interaction.
出处 《中国临床药理学杂志》 CAS CSCD 北大核心 2004年第5期392-394,共3页 The Chinese Journal of Clinical Pharmacology
关键词 抗抑郁药 代谢 细胞色素P450 药物相互作用 antidepressant metabolism cytochrome P450 drug-drug interaction
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