糖尿病肾病患者肱动脉内皮依赖性舒张功能测定及意义

Measurement of endothelium-dependent dilation function of brachial arteries in patients with diabetic nephropathy and its implication

2型糖尿病患者按尿白蛋白排泄率分为单纯糖尿病组 ( 3 0例 ) ,早期糖尿病肾病组 ( 2 4例 )和临床糖尿病肾病组 ( 2 0例 ) ,用高分辨彩色多普勒仪测定肱动脉血流介导的内皮依赖性舒张功能 ,同时测定血循环内皮细胞数。结果显示 3组糖尿病患者的肱动脉内皮依赖性舒张功能依次降低 ,提示此测定可作为反映 2型糖尿病患者血管内皮功能状况和血管病变程度的一项指标。

Type 2 diabetic patients were divided to 3 groups according to their urinary albumin excretion rate: simple diabetic group (n=30), early diabetic nephropathy group (n=24) and clinical diabetic nephropathy (n=20). Endothelium-dependent dilation function of brachial artery was measured by high resolving power colour Doppler echography and circulating endothelial cells in blood were counted. The results showed that endothelium-dependent dilation function of brachial artery in 3 groups declined progressively in the order of simple diabetic group, early diabetic nephropathy group and clinical diabetic nephropathy group, suggesting that this measurement may serve as one parameter reflecting the status of vascular endothelial function and the extent of vascular lesion.