摘要
目的:探讨葛根、蛇菰的解酒毒作用。方法:采用毒理和生化检测方法,了解葛根、蛇菰的安全性及其解酒毒后小白鼠的死亡率和血中乙醇浓度的变化;并观察葛根对酒精性肝损害的病理组织学变化。结果:葛根、蛇菰小白鼠最大耐受量>37.5g/(kg·d),相当于成人用量0.5g/(kg·d)的75倍以上,安全无毒,可以降低小白鼠酒精中毒的死亡率。葛根、蛇菰解酒后小白鼠血中乙醇与对照组比较,差异有显著性(P<O.05),而葛根与蛇菰血中乙醇浓度无差异(P>0.05)。病理组织学提示葛根能减轻酒精性肝损害的肝细胞变性、坏死。结论:中草药葛根、蛇菰具有解酒毒作用,值得进一步研究。
To explore usage of detoxication to alcohol of Gegeng and Shegu. Methods : Through toxicological and biochemistrical ways to understand safety of Gegeng and Shegu. To understand rat dead rate and the change of alcohol. To observate pathological tissue change with Gegeng to alcohol acute liver injury. Results: Maximal toterance dose of Gegeng and Shegu to rat is 37. 5g/ (kg·d) . It is rather safety and decreases the dead rate for alcoholic toxicity. They have remarktable difference (P < 0. 05) with control group of alcohol concentration in blood after Gegeng and Shegu detoxicate alcohol. They have no remarktable difference (P > 0. 05 ) of alcohol concentration in blood of Gegeng and Shegu. Gegeng can derease liver cell degeneration and necrosis of alcoholic acute liver injury. Conclusions: Gegeng and Shegu have detoxication to alcohol
出处
《黔南民族医专学报》
2003年第4期196-198,共3页
Journal of Qiannan Medical College for Nationalities
基金
贵州省黔南州科学技术基金(No.2002018)
关键词
葛根
蛇菰
乙醇
酒精性肝炎
Gegeng
Shegu
alcoholic poisoning
acute liver injury