抑郁症患者的甲状腺功能和细胞因子的研究

Relationship between plasma levels of thyroid hormone and cytokines in depression

目的 探讨抑郁症患者甲状腺功能和细胞免疫功能异常的关系。方法 采用酶联免疫吸附法 (ELSIA)检测 5 8例抑郁症和 30名健康对照的血清游离T3、T4、TSH、IL 2、sIL 2R、IL 10、IL 12水平。结果 抑郁症患者组和对照组间血清T3、T4、TSH、IL 2、sIL 2R、IL 10、IL 12水平无明显差异 (P>0 .0 5 ) ;分型比较发现 ,双相组血清T3水平明显低于对照组 (P <0 .0 5 ) ,T3水平与疾病的严重程度呈显著负相关关系 (P <0 .0 5 ) ;单相组IL 2水平明显低于对照组 (P <0 .0 5 ) ,IL 2水平与T3呈显著负相关关系。结论 单、双相抑郁的病因和发病机制存在免疫或内分泌方面的异质性 ,双相抑郁存在甲状腺功能低下 ,单相抑郁存在由IL 2介导的免疫激活现象。

Objective: To detect the relationship between the abnormal thyroid functions and cellular immunity in patients with depression. Methods: Enzyme-linked immuno-sorbent assay (ELISA) was used to measure the plasma levels of FT3, FT4, TSH, IL-2, SIL-2R, IL-10 and IL-12 in 58 depressive patients and 30 healthy controls. Results: There were no significant differences in plasma levels of FT3, FT4, TSH, IL-2, SIL-2R, IL-10 and IL-12 between the two groups. FT3 level was significantly lower in bipolar patients than that in healthy controls, which was negatively correlated to the seriousness of the disease. IL-2 was significantly lower in unipolar patients than that in the controls, which was negatively correlated to the level of FT3. Conclusion: There were different pathological mechanisms in immunology and endocrinology between unipolar and bipolar depression, which was expressed as hypothyroidism in bipolar patients and immune activation induced by IL-2 in unipolar ones.