阿斯匹林对脑动脉硬化症、脑梗塞恢复期患者血小板聚集和PGI_2及TXA_2合成的影响

prostacyclin and thromboxane A_2 production in patients with cerebral atherosclerosis and cerebral infarction.

本研究观察了阿斯匹林不同剂量对113例脑动脉硬化症和110例脑梗塞恢复期患者血小板聚集和前列腺素及血栓烷素A_2合成的影响。结果表明:不同剂量阿斯匹林对脑动脉硬化症和脑梗塞恢复期患者的疗效是一致的;临床应用小剂量阿斯匹林以50mg/d为最适剂量。小剂量阿斯匹林抗血小板功能和抑制前列环素合成的作用有显著的累加性,但无性别间的差异。

The inhibitory effects of different doses of aspirin on platelet aggregation and prostacyclin (PGI_2) and thromboxane A_2 (TXA_2) production in patients with cerebral atherosclerosis and cerebral infarction were observed. Platelet aggregation by Born's method was induced by adenosine disphosplate (ADP), adrenaline and collagen. PGI_2 synthesis was measured with a radioimmunoassay for its stable metabolite, 6-ketoprostaglandin-F_2, and TXA for its stable metabolite, thromboxaneB_2 (TXB_2). Results indicated that the effects of aspirin in patients with cerebral atheroscierosis accorded with that in patients with cerebral infarction. 50mg/d was the dose of aspirin most likely to produce a rnaximal antiplatelet effect and only a slight inhibiton of prostacyclin production. Cumulative inhibitory effects of low-dose aspirin on platelet aggregation, PG-l_2 and TXA_2 production were significant, but there were no sex differences in the effects of aspirin in this experiment.