摘要
对原发性高血压和高血压伴肥胖患者采用口服葡萄糖耐量试验(OGTT)观察。结果高血压伴肥胖组空腹胰岛素(FSI)、C肽(FS-CP),OGTT后1小时血糖(PBG)、胰岛素(PSI)、C肽(PS-CP)及PSI/PS-CP比值显著高于原发性高血压组及对照组,PBG/PSI比值显著低于原发性高血压组及对照组。多因素分析显示高血压病人的PSI与舒张压呈显著正相关。高血压伴肥胖病人PSI的异常升高除与胰岛β细胞分泌增加有关外。还与肝脏对胰岛素清除率下降有关。
Responses of plasma glucose,serum insulin and C-peptide with oral glu- cose tolerance test were measured in 17 non-obese,25 obese hypertensive and 20 non-obese normotensive subjects of comparable age.The obese hypertensive patients had lower 1h glu- cose/insulin and higher 1 h insulin/C-peptide ratios than those in non-obese hypertensive and normotensive subjects.In multiple regression analysis,diastolic blood pressure in hyperten- sive patients showed positive correlation with the 1 h serum insulin(r=0.4330,P<0.05). These data indicated that obesity was closely associated with the insulin level and insulin may play an important role in the regulation of blood pressure of hypertensive paticnts and that the abnormal increase of the insulin in obese hypertensivce paticnts was associated with low hepatic insulin clearance in addition to high pancreatic insulin secretion.
关键词
高血压
肥胖
胰岛素耐受性
hypertension
obese
insulin resistance
glucose tolerance test