单扫描示波极谱法检测哌拉西林钠

Single-sweep Oscillopolarphic Determination of Piperacillin Sodium

在0.66mol／L KCl(pH=6.70)的底液中,哌拉西林钠在汞电极上有一灵敏的导数还原峰,其峰电位Ep=-1.23V(vs.SCE).峰电流与哌拉西林钠的浓度在8.0×10-6至7.0×10-8mol／L范围内呈良好线性关系(r=0.9992),检出限为4.5×10-8mol／L,该法应用于注射用哌拉西林钠中哌拉西林钠含量的测定,结果令人满意。实验表明,该体系为一具有吸附性的不可逆过程。

In a supporting electrolyte containing 0.66 mol/L KCl(pH=6.70), a sensitive reduction peak of piperacillin sodium was found by single-sweep oscillopolarography. The peak potential of piperacillin sodium was -1.23v(vs.SCE). There was satisfactory linear relationship between peak current and the concentration of analytes in the concentration range of 8.0×10-6-7.0×10-8 mol/L(r=0.9992) for pipercillin sodium with the detection limits of 4.5×10-8 mol/L. The methods were applied to the determination of piperacillin sodiumin the sample of drugs with satisfactory results. This indicated an irreversilde process with adsorption.