疏肝汤利胆汤对家兔Oddi氏括约肌肌电的影响

EFFECT OF DECOCTION SOOTHING THE LIVER AND DECOCTION DISCHARGING BILE ON MYOELECTRO OF ODDI'S SPHINCTER IN RABBITS

通过对家兔中药灌胃前后Oddi氏括约肌肌电变化的观察,探讨疏肝汤和利胆汤利胆排石作用的机理。实验证明,疏肝汤使Oddi氏括约肌放电频率增多,紧张性加强,有利于胆汁贮存;利胆汤使Oddi氏括约肌放电频率减少,紧张性降低,有利于胆汁排放。二方协同作用,可增加胆汁排放的“内冲击力”,为结石排出创造了条件。硫酸阿托品可阻断利胆效应,提示利胆效应与迷走神经的兴奋性存在密切关系。

Changes of myoelectro of Oddi's sphincter of rabbits were observed after feeding decoction soothing the liver and discharging bile to probe into the mechanism. The results show that the discharge frequency of Oddi's sphincter and its tensity increase after taking the decoction soothing the liver, however the discharge frequency and tensity decrease after taking the decoction discharging bile, The cooperation of the two decoction will facilitate bile excretion and so the gallstones. Atropine sulfate can block the cholagogic effect suggesting the effects of the two decoction are related to excitation of vagus nerve.