摘要
目的研究胶原诱导性关节炎大鼠滑膜基因表达谱,探讨类风湿关节炎的发病机制。方法用含588个基因的大鼠基因表达谱芯片研究胶原诱导性关节炎及正常大鼠滑膜基因表达谱。结果胶原诱导性关节炎大鼠差异表达基因共有68个,上调基因有63个,下调基因有5个。结论胶原诱导性关节炎是一个涉及多基因表达异常的全身免疫性疾病,筛选到的差异表达基因将为进一步研究类风湿关节炎发病机制及防治提供重要线索。
Objective To study synovitis gene expression profile of CIA rats and then to explore the mechnism of rheumatoid arthritis (RA) pathogenesis. Methods cDNA microarray chips containing 588 rat target genes were used to identify gene expression profile in synovitis of CIA rats and normal rats. Results Among the target genes, 68 differentially expressed genes were identified in CIA rats. Sixty-three genes were up-regulated and 5 genes were down-regulated. Conclusion CIA is an immunogenic disorder with many abnomal expression genes. Genes screened from the target can provide important information for futher study and treatment of RA.
出处
《中华风湿病学杂志》
CAS
CSCD
2005年第1期31-33,共3页
Chinese Journal of Rheumatology
基金
国家自然科学基金资助项目(30371833)
湖南省科技基金资助项目(02ssy4028)
湖南省中医管理局基金资助项目(20053)
