链脲佐菌素诱导实验性糖尿病大鼠模型建立的研究

Study on experimental diabetes animal model in rats induced by streptozotocin

目的:研究链脲佐菌素诱导实验性糖尿病大鼠模型的建立,并观察不同途径给药诱导的差异。方法:采用腹 腔注射或尾静脉注射链脲佐菌素,检测空腹血糖及胰岛素。结果:腹腔注射或尾静脉注射组均出现血糖升高、胰岛素下 降,和对照组相比有显著性差异(P<0.01),两组之间无显著性差异(P>0.05)。结论:腹腔注射或尾静脉注射链脲佐菌 素均可诱导实验性糖尿病大鼠模型建立,两种途径无显著性差异。

Objective To study the experimental diabetes animal model in rats induced by streptozotocin and explore the difference in different ways. Methods The diabetic model of Wistar rats was duplicated with streptozotocin once introperitoneally or intratailvenously. The blood glucose and plasma insulin levels were detected. Results Blood glucose levels in streptozotocin groups were increased significantly as compared with control group (P < 0. 01). Plasma insulin levels in streptozotocin groups were decreased significantly as compared with control group (P<0. 01), while there was no significant difference between different ways(P>0. 05). Conclusion The diabetic model of Wistar rats could be duplicated with streptozotocin once intrapertoneally or intratailvenously,while there was no significant difference between two ways.