用Metriscan骨密度仪研究西藏廊坊正常人群骨密度的变化规律

Investigation on bone mineral density in normal group in Lang Fang,Beijing and Lhasam, Tibet

目的研究不同海拔、不同种族、不同纬度(地区)正常人群骨量分布差异,确定峰位骨量的年龄段,寻找骨量丢失规律,为临床制定骨质疏松诊断标准提供参考值.方法选择西藏拉萨11～79岁616名健康藏族男女,河北廊坊地区11～89岁1122名健康汉族男女,以10岁为一年龄段,对男女分别进行分组.用MetriscanTM(美国Alara公司提供,其原理是用放射吸收技术评估相对的指骨骨密度)指骨骨密度仪,对非习惯用手的2nd、3rd、4th手指中节进行测量,取结果的平均值.数据结果采用SPSS10.0软件进行统计学分析.结果峰值骨量藏汉男女都在30～39年龄段.骨量丢失12%以上藏族男性是在70～79年龄段,汉族男性是在80～89年龄段;藏汉女性都在50～59年龄段.藏族女性60～69年龄段骨量丢失已达24.35%,汉族女性70～79年龄段骨量丢失才达23.86%,与汉族相比藏族骨量丢失速率较快;但两地不同年龄段骨量均数比较,男性20～69年龄段两地对比有显著差异,藏族骨密度明显高于汉族;女性11～49年龄段有显著差异,藏族明显高于汉族;其它年龄段虽没有显著性差异,但也是藏族高于汉族.结论女性在绝经前男性在衰老前廊坊汉族和西藏藏族正常成人骨密度有显著差异;女性在绝经期后,男性在衰老后没有显著差异.其差异原因是地域、海拔不同还是种族差异引起有待于进一步研究.骨量丢失规律符合生理年龄预诊法.

Objective a.To conduct research on the bone mass variation of the normal different ethnic group living in different altitude and latitude. b. To define the age of the peak bone mass and find the regularity of bone loss. c. To provide the reference for clinical osteoporosis diagnostic criteria. Methods Select 616 Tibetan healthy males and females aging from 11 to 79 and 1122 healthy Han males and females from Lang Fang, He Bei Province aging from 11 to 89 and group them by gender and 10 year age segment. Use the MetriScan from Alara Company to measure the middle part of 2nd, 3rd and 4th less frequently used fingers to obtain the mean value. We use the software SPSS 10.0 to process and analyze the data. Results For Tibetan male and female, peak bone mass appears at the age of 30 to 39. Over 12 % bone loss rate is observed for Tibetan male aging from 70 to 79, for Han male aging from 80 to 89 and for Tibetan female aging from 50 to 59. 24.35 % bone loss rate is reached by the Tibetan female aging from 60 to 69 whereas we only notice a 23.86% loss rate among Han female aging from 70 to 79. It is obvious that Tibetans have higher loss rate than Hans. Bone density of Tibetans is significantly higher than Hans in male age group from 20 to 69 and female age group from 11 to 49. There is no significant difference among other age groups, still, Tibetan is little higher. Conclusions We have observed a significant difference of bone density in premenopause women and males before aging in Hans in Lang Fang and Tibetans. The difference is un-noticeable in post menopause women and males after aging. Further research needs to be conducted to define the actual cause, geography, altitude or race? The bone loss regularity agrees with the physiological age preliminary diagnosis.