摘要
我们曾报道原发性高血压患者(EHS)红细胞抗高血压因子(AHF)具有缓慢而持久的降压作用。本工作表明,AHF对卒中易感型自发性高血压大鼠(SHRsp)还具有快速短暂的降压作用,注射AHF后10—30s,SHRsp收缩压从原水平的26.8±1.7kPa降至20.1±1.5kPa(P<0.001)。正常人和大鼠红细胞AHF的降压作用明显强于EHS和高血压大鼠AHF。此外我们还发现EHS血浆中存在升压物质。以上结果提示,AHF缺乏和升压物质含量相对较高可能是原发性高血压发病的一个重要原因。
We previously demonstrated the presence of a long-acting antihypertensive factor(AHF) in the erythrocytes of essential hypertensive subjects(EHS). The present in-vestigntion demonstrates further that the AHF is also capeble of producing a rapid andtransient blood pressure lowering effect in stroke prone sportaneously hypertensiverats (from 26.8±1.7 to 20.1±1.5 kPa by 10--30 s, P<0.001). An evenmore stronger antihypertensive effect could be found if the AHF prepared from nor-mal subjects or rats was used. We also found that some hypertensive factor was pre-sent in EHS plasma, but not in normal subjects. The results of the present paper sug-gest that AHF deficiency and higher level of pressor substance may play an importantrole in the development of essential hypertension.
出处
《生理学报》
CAS
CSCD
北大核心
1993年第3期262-269,共8页
Acta Physiologica Sinica
关键词
高血压
红细胞
抗高血压因子
essential hypertension
spontaneously hypertensive rat
erythrocyte
antihypertensive factor
hypertensive substance