摘要
目的 探讨IFN γ、IL 4与GBS的关系。方法 用双抗夹心酶联免疫 (ELISA)法测定GBS患者急性期、恢复期血清中IFN γ及IL 4的水平。结果 IFN r水平在GBS患者急性期血清中较OAND、OND、NC组显著升高 ,恢复期血清中下降 (P <0 0 5 )。GBS患者组急性期血清IL 4水平较NC组无显著性差异 ,恢复期则显著升高 (P <0 0 5 )。GBS重型患者急性期血清IFN γ水平较轻型患者升高 ,IL 4水平较轻型患者降低 (P <0 0 5 )。结论 IFN γ可能在GBS的发生发展中起重要作用 ,IL 4可能对GBS的发展起抑制作用 ,与疾病的恢复有关。血清IFN γ及IL 4的水平反映GBS患者疾病的严重程度 ,并能反映患者的免疫状态 ,为GBS的免疫治疗提供了依据。
Objective To study the relation of IFN-γ、IL-4 and GBS.Methods Levels of IFN-γ and IL-4 in the serum of acute and recovery phase patients with GBS were measured by double antibody sandwich enzyme linked immunesorbent assay (ELISA).Results Serum levels of IFN-γ in the patients with acute GBS were significantly higher than those in the subjects with OAND,OND or NC. Serum levels of IFN-γ in the patients with recovery GBS were lower than those(P<0.05).Serum levels of IL-4 in the patients with acute GBS were not higher than those of NC subjects. Coinciding with recovery, elevated serum levels of IL-4 in patients with GBS were determined significantly higher than those in their early disease course. Both increased serum concentrations of IFN-γ and decreased serum concentrations of IL- 4 in patients with acute GBS correlated directly with diseases severity (P<0.05).Conclusion IFN-γ may play an important role in immunopathology of GBS. IL- 4 may contribute to the termination of the disease promoting process by downregulating immuno. Levels of IFN-γ or IL- 4 may serve as a marker of clinical immunological diseases which reflect disease severity,and provide theoretical basis for immunotherapy in GBS patients.
