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血管紧张素转化酶2的研究进展 被引量：1

Progress on Angiotensin-converting Enzyme-related Carboxypeptidase(ACE2)
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摘要 2000年,科学家们发现了一种与血管紧张素转化酶(ACE)具有较高同源性的酶,命名为ACE2(或ACEH)。ACE2与ACE均具有HEXXH锌离子结合结构域,也属于肾素-血管紧张素系统(RAS),但ACE2中还具有一个特异的collectrin结构域。ACE2不仅在心血管系统中发挥了重要的功能,而且作为SARS病毒入胞的受体在肺部疾病中发挥了一定作用。此外,由于其组织特异性,可能在生殖系统及胃肠道系统中也扮演了重要的角色。 ACE2 (or ACEH), the first homologue of human angiotensin-converting enzyme (ACE), was identified in 2000. This zinc metalloprotease belongs to the renin-angiotensin system. The ACE2 protein may evolve as a chimera of a single HEXXH zinc-binding domain and a collectrin domain. ACE2 is not only an essential regulator of heart function, but also a receptor of the SARSCoV spike glycoprotein in mediating virus entry and cell fusion. Furthermore, it may also play some roles in the physiology and pathophysiology of gastrointestinal and reproductive systems, in view of its organ-and cell-specific expression of ACE2.
作者 鲍羿(综述) 洪斌(审阅)
机构地区 中国医学科学院
出处 《医学分子生物学杂志》 CAS CSCD 2005年第1期53-56,共4页 Journal of Medical Molecular Biology
基金 "十五"国家重大专项(No.2002AA2Z343D)~~
关键词 ACE2/ACEH 心血管疾病 严重急性呼吸道综合征 ACE2/ACEH cardiovascular disease severe acute respiratory syndrome
分类号 Q71 [生物学—分子生物学]
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参考文献20

  • 1[1]Eriksson U, Danilczyk U, Penninger JM. Just the beginning: novel functions for angiotensin-converting enzymes. Curr Biol, 2002, 12(21): R745-52.
  • 2[2]Donoghue M, Hsieh F, Baronas E, et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res, 2000, 87(5): E1-9.
  • 3[3]Tipnis SR, Hooper NM, Hyde R, et al. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem, 2000, 275(43): 33 238-43.
  • 4[4]Vickers C, Hales P, Kaushik V, et al. Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J Biol Chem, 2002, 277(17): 14 838-43.
  • 5[5]Turner AJ, Tipnis SR, Guy JL, et al. ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors. Can J Physiol Pharmacol, 2002, 80(4): 346-53.
  • 6[6]Zhang H, Wada J, Hida K, et al. Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys. J Biol Chem, 2001, 276(20): 17 132-9.
  • 7[7]Harmer D, Gilbert M, Borman R, et al. Quantitative mRNA expression profiling of ACE2, a novel homologue of angiotensin converting enzyme. FEBS Lett, 2002, 532(1-2): 107-10.
  • 8[8]Towler P, Staker B, Prasad SG, et al. ACE2 X-ray structures reveal a large hinge-bending motion important for ihibitor binding and catalysis. J Biol Chem, 2004, 279(17): 17 996-8 007.
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同被引文献28

  • 1宋仕玲,龚作炯.肾素-血管紧张素系统在肝病中的作用[J].人民军医,2004,47(12):739-741. 被引量：7
  • 2李旭,孟莹,姜泊,杨希山,王卫卫,郭丹,赖卓胜,张振书.血管紧张素Ⅱ和醛固酮对肝星状细胞核因子κB信号转导通路的影响[J].中华医学杂志,2005,85(6):374-380. 被引量：11
  • 3赵海军,郭顺根,贾文婷,庞奕晖,戚红丹,牛建昭.肝纤维化肝窦内皮细胞对肝星状细胞的影响[J].解剖学杂志,2006,29(4):514-516. 被引量：3
  • 4Bataller R, Brenner D A. Liver fibrosis [ J]. J Clin Invest, 2005, 115(2) : 209-218.
  • 5Munshi M K, Uddin M N, Glaser S S. The role of the renin-angio- tensin system in liver fibrosis [ J ]. Exp Biol Med( Maywood ) , 2011, 236(5) : 557-566.
  • 6Friedman S L, Rockey D C, Bissell D M. Hepatic fibrosis 2006: re- port of the Third AASLD Single Topic Conference [ J ]. ttepatology, 2007, 45 ( 1 ) : 242-249.
  • 7Tsang S W, Ip S P, Leung P S. Prophylactic and therapeutic treat- ments with AT1 and AT2 receptor antagonist and their effects on changes in the severity of pancreatitis [ J]. Int J Biochem Cell Biol, 2004, 36(2) : 330-339.
  • 8Herath C B, Warner F J, Lubel J S, et al. Upregulation of hepatic angiotensin-converting enzyme 2 ( ACE2 ) and angiotensin- ( 1-7 ) levels in experimental biliary brosis [ J l. Joumal of Hepatology, 2007, 47 ( 3 ) : 387-395.
  • 9Lu P, Liu H, Yin H, et al. Expression of angiotensinogen during hepatic fibrogenesis and its effect on hepatic stellate cells [ J]. Med Sci Monit, 2011, 17(9) : 248-256.
  • 10Danilczyk U, Eriksson U, Crackower M A, et al. A story of two ACEs [J]. J Mol Med (Berl), 2003, 81(4) : 227-234.

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医学分子生物学杂志
2005年 第1期

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