余甘子抗家兔动脉粥样硬化的实验研究

Effect of Emblica officinalis on Formation of Atherosclerotic Plaque in Hypercholesterolemia Rabbits

目的观察余甘子果汁粉对食饵性高脂血症家兔血脂及实验性动脉粥样硬化形成的病理学的影响。方法20只日本长耳白兔被随机分为三组,正常对照4只,饲以普通饲料。第二组:高脂组,8只,饲以高脂饲料(0.5％胆固醇及15％蛋黄粉)。第三组:余甘子组(预防组),8只,饲以高脂饲料(0.5％胆固醇及15％蛋黄粉)加余甘子果粉4g。动物单笼饲养,饮水不限,自由摄食,每日进食150g。分别于第0、6、12周时测定血液中的胆固醇、甘油三酯及高密度脂蛋白胆固醇的含量,并于12周后放血法处死,运用图象分析法测定主动脉内膜粥样硬化斑块面积。结果余甘子能使高胆固醇饮食家兔的血浆中的TC、TG、LDL-C的含量分别降低42％、29％、31％并使HDL-C的含量升高33％,同时使动脉粥样硬化斑块的面积减少38％。结论余甘子能抑制主动脉粥样硬化的形成。

Objective To investigate the effects of fruit powder of Emblica officinalis on the blood lipid and the formation of atherosclerotic plaque of aorta in rabbits with dietary hypercholesterolemia Methods Twenty Japanese long ear rabbits were assigned to 3 groups: 4 rabbits in control group were fed only with normal diet; 8 rabbits in 'high lipid' group were fed with food contained 0.5% cholesterol and 15% powdered egg. 8 rabbits in 'Emblica officinalis' group were fed with food contained 0.5% cholesterol, 15% powdered egg and fruit powder of Emblica officinalis. The content of serum TC, TG, LDL- C and HDL - C were mensurated on the 0, 6 and 12week. All rabbits were killed after 12 weeks and used to study the atherosclerotic plaque on aorta endothelium with method of image analysis. Results Emblica officinalis reduced by 42% ,29% and 31% the contents of serum TC, TG, and LDL -C, and increase by 33% the contents of serum HDL - C. Emblica officinalis also decreased by 38% the plaque areas. Conclusions Emblica Officinalis can decrease the blood lipid and inhibit the formation of atherosclerosis of aorta