二巯基丙磺酸钠治疗毒鼠强中毒血清毒鼠强浓度变化与疗效观察

The Change of Serum Tetramine Concentration and Clinical Effect of Na-DMPS in Treating Acute Tetramine Intoxication

目的探讨二巯基丙磺酸钠(Na-DMPS)治疗毒鼠强中毒血清毒鼠强浓度的动态变化及临床疗效。方法将我院2001年11月2002年10月给予常规治疗的30例急性毒鼠强中毒患者作对照组;将2002年11月至2003年10月收治的24例作治疗组。治疗组除常规治疗外,另加 Na-DMPS。观察血清毒鼠强变化、抽搐次数、控制抽搐时间,并进行比较。结果治疗组与对照组治疗1、2周后血清毒鼠强浓度、抽搐次数和控制抽搐时间差异均有显著性(P<0.05)。结论 Na-DMPS 对急性毒鼠强中毒疗效明显,可降低血清毒鼠强浓度,从而缩短抽搐时间,降低抽搐强度,延长抽搐间隔时间,减轻器官功能损伤,缩短治疗时间,提高治愈率。

Objective To evaluate the change of serum tetramine concentration and clinical effect of Na-DMPS in treatment of acute tet- ramine intoxication.Methods 30 cases of acute tetramine intoxication received routine treatment were regard as the control group,and 24 cases treating in the recent one year were given routine treatment plus Na-DMPS as abserved group.The change of tetramine concentration and relief of intensify of convulsion were observed.Results The results between the two groups in frequency and duration of convalsions showed remarkable differences(P<0.05).Conclusion Treatment of acute tetramine intoxication with Na-DMPS had a remarkable effect, it might decrease the concentration of serum tetramine,shorten convulsion time,decreased convulsion intensify and prolong convulsion inter- val.Therefore it could relieve organic functional injury,shorten treating time and increase the curative rate.