壳聚糖口腔复合药膜的研究

Preparation of oral composite chitosan film

目的选择壳聚糖作为膜载体,加入芦荟、表皮生长因子(EGF)等药物制备口腔复合膜,探讨各成分的最佳组配方案及药膜的理化性质.方法①将壳聚糖制成膜;筛选各种药物的组配方案.②测定复合膜的理化性质.结果①复合膜厚约0.5mm,质地均匀,外观为红棕色,黏性较好,遇水2min后呈胶膏状,可牢固黏附于黏膜之上.复合膜每平方厘米含水溶性壳聚糖0.007g、芦荟全叶冻干粉0.051g、EGF40IU、丁卡因0.533mg.25℃,1%的复合膜水旋浮液的pH值为6.8±0.1.复合膜在37℃水中的溶化时间为60～90min.②复合膜具有较好的释放性能,可在2～2.5h内释放出绝大部分药物.结论本实验研究表明水溶性壳聚糖是一种良好的膜载体材料,加入芦荟、EGF等不影响其黏附性;而且其药物释放性能很好,可保证药物的有效释放.

Objective To select chitosan as film carrier, then add aloe vera, epidermal growth factor (EGF)et al to prepare oral composite film. To explore the most optimal combination of various compound and the physical-chemical nature of drug film. Methods ①To prepare the composite film with chitosan , EGF and aloe vera et al. ②To determine the physical-chemical nature of this film. Result ① The thickness of composite film was about 0.5mm and drug was well-distributed. The film looked like red-brown and its adherence was good. If it contacted with water after 2 minutes, it would become glue-confection and adhere mucosa strongly. It contained 0.007 gram chitosan, 0.051 gram aloe vera, 40IU EGF, 0.553 mg dincaine per cm2 film. The pH of 1% water solution of composite film was 6.8±0.1 at 25 ℃. The melting time in water was about 60-90 minutes. ②Composite film had good releasing capacity which could release most drug in 2-2.5 hours. Conclusion The result indicated that water-soluble chitin was a kind of good mucal carrier material , and when it is added to aloe, EGF et al it does not affect its adherence; further its drug release is good and guarantees efficient release.