哮喘患者血红素氧合酶 一氧化碳体系的观察

目的 探讨血红素氧合酶 (HO -1)和内源性一氧化碳 (CO)在哮喘患者中的改变及可能的作用。 方法 哮喘患者急性发作期治疗前抽血测定HO -1和HbCO ,并和正常人群进行比较。 结果 哮喘患者急性发作期HO -1、HbCO为 ( 0 .167± 0 .0 3 2 )、( 5 .115± 0 .92 1) ,明显高于正常人群 ,( 0 .0 43± 0 .119)、( 1.2 0 3± 0 .5 0 1) ,(p<0 .0 0 1)。 结论 哮喘患者血HO -1、CO明显高于正常人群 ,可能参与了哮喘的病理生理过程 。

Objective To explore the change and relevant effect of heme-oxygenase-1(HO-1) and endogenous carbon-monoxide in asthma patients. Methods Forty people took part in the study, twenty in control group and twenty in asthma group. The blood HbCO concentration and HO-1 activity were measured. Results The activity of HO-1 and HbCO of asthma group were (0.167±0.032) and (5.115±0.921) respectively,which were significantly higher than those of the control people,(0.043±0.119)、(1.203±0.501),(P<0.001). Conclusion The asthma patients' blood HO-1 activity and CO concentration were significantly higher than normal people underlying that people's CO/HO-1 system might involve in the pathological process; and also involve in self-regulation of hypoxic pulmonary blood vessel reconstuction.