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决明子对实验性高胆固醇血症和动脉粥样硬化的抑制作用及其机理探讨 被引量:65

STUDY ON THE PREVENTIVE EFFECT AND ITS MECHANISM OF CASSIA SEED ON ATHEROSCLEROSIS CAUSED BY HYPERCHOLESTEROLEMIA
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摘要 根据血清胆固醇水平、主动脉壁病变范围及胆固醇沉积量等指标,观察决明子对家兔实验性高胆固醇血症的影响,证明决明子具有降低血清低密度脂蛋白胆固醇、抑制动脉粥样硬化斑块形成的作用。为了探明决明子的有效成分和作用机理,用大鼠做了分份实验,结果表明蒽醌糖甙通过缓泻作用,增加粪中固醇排出量,从而说明蒽醌糖甙是决明子发挥治疗作用的重要成分。 The influence of cassia seed on experimental hypercholesterolemia in rabbits was observed to show that the cassia seed decreased the serum cnolesterol level and attenuated the atheroslerosis in aorta. To clarify the mechanism, the anthrancene glycoside and acidic glycan of cassia seed were isolated. Their effect on the amount of sterol excreted in rat stool was analysed. It was shown that anthrancene glucoside was the main effective component in decreasing the intestinal sterol excretion through mild diarrhoea.
出处 《浙江医科大学学报》 CSCD 1993年第6期246-249,共4页
关键词 决明子 胆固醇过多 动脉粥样硬化 Chinese medicinal herbs Cassia seed/pharm Hypercholesterolemia/drug ther Atherosclerosis/drug ther
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