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山药对糖尿病小鼠血糖、血脂、肝糖元和心肌糖元含量的影响 被引量:27

The Influence of Dioscoren Opposita Thunb on the Contents of Glucose and Tri-acylglycerol in Plasma and Glycogen in Liver and Myocardium Tissue of Diabetic Mice
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摘要 目的:观察山药的抗糖尿病作用效力。方法:采用四氧嘧啶制作糖尿病小鼠模型,并以优降糖作阳性对照。连续21天用不同剂量的山药灌胃治疗,比较各组生化指标的差异。结果:①与对照组比,剂量在6.00g/Kg·d(-1)以上的山药各组的血糖和血脂含量较低(P<0.001或P<0.05),而肝糖元和心肌糖元含量较高(P<0.001或P<0.01)。②与优降糖组比,剂量在6.00g/Kg·d(-1)以上的山药各组的血糖、血脂和心肌糖元含量较高(P<0.001或P<0.01),而肝糖元含量较低(P<0.01)。结论:山药有一定的抗糖尿病作用,但效力显著弱于优降糖,且需剂量大。 Objective To observe the antidiabetic effect of Dioscoren Opposita Thunb (DOT). Methods The diabetic mice model was established by intra-abdominal injection of alloxan,then the living mice were divided into five groups three of them were respectively treated with different dose of DOT; one group was treated with glibenclamide as standard control; and another one was non-treated as experimental control. After a periode of 21-day treatment, the relevant biochemical indexes were determined. Results ①Comparing with the experimental control group, in DOT group (dosage>6. 00g/kg·d(-1) ) the content of glucose and tri-acylglycerol in plasma were lower (P< 0. 001 or P< 0. 05 ), but glycogen in liver and myocardium tissues was higher (P< 0.001 or P<0. 01 ). ②Comparing with glibenclamide group, in DOT group (dosage > 6. 00g/kg·d(-1) ) the contents of glucose and tri-acylglycerol in plasma were higher (P < 0. 001 ), and the glycogen in liver tissues was lower (P< 0. 001 ) but in myocardium was higher (P< 0. 01 ). Conclusion DOT has a certain anti-diabetic effect when its dosage is massive, and the effect is much lower than that of glibenclamide.
出处 《咸宁医学院学报》 1998年第4期223-226,共4页 Journal of Xianning Medical College
关键词 糖尿病 山药 葡萄糖 甘油三酯 糖元 血浆 肝脏 心脏 Diabetes Dioscoren opposita Thunb Glucose Tri-acylglycerol Plasma Liver Myocardium Mice
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