臭牡丹抗肿瘤作用研究

Studies on the Antitumor Effect of Clerodendrum bungei Steud or C.foetidum Bge.

臭牡丹提取物B部分腹腔或皮下注射均能延缓S_(180),H_(22)的生长;干扰S_(180)肿瘤细胞DNA代谢,抑制腹腔巨噬细胞的吞噬功能及其SRBC所致溶血素抗体的产生。臭牡丹提取物C部分对H_(22)肿瘤也有抑制作用。

Clerodendrum B(Ⅰ) at dosage of 100g/kg ip or sc for 7 days was shown to have antitumor effect on hepatic carcinoma and sarcoma 180 in mice. In the mean time, 100g/kg sc of(Ⅰ) interrupted ~3H-TdR incorporation into DNA of sarcoma 180 cells in mice, 100.10g/kg sc of (Ⅰ) could suppress the phagocytic activity of the peritoneal macrophage against the CRBC (chieken red blood cells) in mice, 100g/kg sc of (Ⅰ) also made the production of serum hemolysin less than one half of that of the control in mice immunized with SRBC. Clerodendrum C at 100g/kg could inhibit the growth of hepatic carcinoma in mice