摘要
报告严重体表烧伤后1个月以内,大鼠脑部病变的动态变化,经光镜、电镜及组化观察,见毛细血管内皮细胞肿胀、饮泡增多、出现小管及连接部分离等变化;神经原及胶质细胞变性、坏死,细胞器肿胀、减少或消失;出现血管周围胶质细胞套及类噬神经原现象等变化。自伤后6h开始,3天时最明显,30天时大多数病变明显减轻或恢复正常。讨论了主要病变的意义及发生原理。
This paper reports the dynamic patho—morphological changes of brain in rats within one month after severe extensive burn (30% TBSA, Ⅱ°—Ⅲ°)by light microscope, electron microscope and histochemistry. The brain tissues exhibited conspicuous and consistent morphological changes. They were characterized by: (1) swelling of endothelial cells associated with increase in number of pinocytotic vesicles, tubular structure, formation of endothelial gap; (2)degeneration, necrosis, and swelling, decreased or disappearance of organelle in neuron and neuroglia cells; (3) perivascular neuroglia cuffs; (4) neuronophagiod phenomenon. The lesions appeared at 6hr postburn, and it became more marked with elapse of time and became prominent at 3d posthurn. Most of the lesions were mild and disappeared at 30d postburn. The significance and pathogenesis of the main lesions were discussed.
