摘要
三七皂甙为人参三七的根提炼出来的有效成分。本实验目的是从细胞水平上探讨三七皂甙抗心律失常的作用及其机理,结果显示:三七皂甙能明显改善缺氧和再供氧对心肌细胞电效应的影响,但对异丙肾上腺素引起的心肌细胞电效应没有明显的影响。提示三七皂甙能提高心肌细胞耐缺氧能力和对抗再供氧造成的损害,但其抗心律失常作用机理可能并非通阻断β受体的途径。
The saponin of Radix Notoginseng(SRN)is an effective component extractedfrom Radix Notoginseng.The purpose of this study is to explore the antiarrhy-thmic action of SRN and its mechanism at a cell level.The results showed thatSRN can improve the influence on myocardial cellular electric effect caused byhypoxia and reoxygenation, but exerts no influence on that caused by isopro-terenol.It is suggested that SRN can increase the tolerance of myocardial cellstoward hypoxia and counteract the damage caused by reoxygeration, but itsantiarrhythmic mechanism may not be through the β-receptor.
关键词
三七
三七皂甙
药理学
心律失常
中医药疗法
RADIX NOTOGINSENG/pharm. @SAPONINS OF RADIX NOTOGINSENG/pharm.ARRHYTHMIA/TCM ther.MYOCARDIUM/drug eff